Researchers at the Institute of Biophysics, Chinese Academy of Sciences, and a professor at the University of Science and Technology Beijing= have made new advances in stem cell-nano wound materials. The collaborative team has developed a nanofiber aerogel with excellent antibacterial and antioxidant properties that can synergistically promote wound healing.

Skin stem cells, a class of cells with strong proliferative capacity, are abundantly present in human hair follicle tissue. When the skin is damaged, has a large wound or is difficult to heal, as in the case of diabetic skin damage, the use of hair follicle stem cells with high proliferation capacity can help repair and heal the broken wound. The team previously found that nanomaterials are effective in vascular repair of skin wounds. By applying the repairing ability of stem cells and combining them with new nanomaterials, a stem cell-nano "Band-Aid" was developed. Unlike the weak function of traditional Band-Aids in promoting wound healing, the nanofiber in the new material is a fiber finer than one thousandth of a hair, highly similar to the structure of extracellular matrix, which can be obtained by electrostatic spinning.

By physically and chemically modifying the nanofibers, the team group obtained a variety of structural and functional nanofiber wound dressings. Thanks to continuous structural improvements, they developed nanofiber dressings with good elasticity to resist wound damage from external pressure and adapt to the shape of wounds at different times as they heal.

The team also prepared a new generation of nanofiber dressing that can regulate wound exudate, which has a variety of bioactive functions that can protect against bacteria externally and regulate the wound microenvironment internally. The functional nanofiber dressing was shown to rapidly promote chronic wound healing in a diabetic mouse wound model. This nanoscale wound dressing is simple to prepare and functional, and is expected to become a new generation of "Band-Aid".

• by Esther
• Aug 21,2021
• Topics
• 29

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